Asteggiano C, Tolosa N, Pereira R, Moreno J, Cañas F
Acta Physiol Lat Am. 1981;31(2):77-83.
The effects of vitamin D3 and the aqueous extract of Solanum malacoxylon on intestinal alkaline phosphatase and tissue phosphate content were studied on rachitic chicks treated with large doses of ethane-1-hydroxy-1,1 diphosphonate (EHDP). The EHDP treatment blocks the increase of intestinal calcium or phosphate absorption induced by the vitamin D3, while it has no effects on the rise of intestinal alkaline phosphatase activity or the increment in tissue phosphate content. The lack of correlation between the increment of alkaline phosphatase and that of Ca or phosphate absorption in vitamin D3 plus EHDP treated chicks excludes a participation of the alkaline phosphatase in the mechanism of Ca or P intestinal absorption. The Ca or phosphorus absorption are elicited specifically by 1,25-(OH)2-D3, while alkaline phosphatase activity and phosphate tissue concentration respond to a broader spectrum of stimuli.
在大剂量乙烷-1-羟基-1,1-二膦酸盐（EHDP）处理的佝偻病雏鸡上，研究了维生素D3和茄软刺木水提取物对肠道碱性磷酸酶及组织磷酸盐含量的影响。EHDP处理可阻断维生素D3诱导的肠道钙或磷酸盐吸收增加，但对肠道碱性磷酸酶活性升高或组织磷酸盐含量增加无影响。在维生素D3加EHDP处理的雏鸡中，碱性磷酸酶增加与钙或磷酸盐吸收增加之间缺乏相关性，排除了碱性磷酸酶参与钙或磷肠道吸收机制的可能性。钙或磷的吸收是由1,25-(OH)2-D3特异性引发的，而碱性磷酸酶活性和磷酸盐组织浓度对更广泛的刺激有反应。
