DeRemee R A, Rohrbach M S
Chest. 1984 Jan;85(1):45-8. doi: 10.1378/chest.85.1.45.
Twenty-four patients with sarcoidosis had normal serum angiotensin converting enzyme (SACE) values at time of diagnosis. Sixteen patients were in stage I and eight of these underwent complete remission and four followed a stable course. Seven of eight patients in stages II and III experienced improvement while receiving glucocorticoid treatment. In six, serial SACE measurements fell significantly, paralleling the clinical improvement. The data suggest that a normal SACE in stage I indicates a good prognosis. Patients in stages II and III with normal SACE levels may still have active disease potentially responsive to glucocorticoid treatment. The reduction of SACE while receiving treatment may be viewed as the "suppressible" SACE compartment, representing that portion of the enzyme elaborated by the granuloma or its cellular precursors. The level remaining after suppression by glucocorticoids may be considered "basal" SACE, probably related to normal turnover of SACE producing cells in vascular endothelium.
24例结节病患者在诊断时血清血管紧张素转换酶（SACE）值正常。16例患者处于I期，其中8例完全缓解，4例病情稳定。II期和III期的8例患者中有7例在接受糖皮质激素治疗时病情改善。6例患者的SACE系列测量值显著下降，与临床改善情况平行。数据表明，I期SACE正常提示预后良好。II期和III期SACE水平正常的患者可能仍有活动性疾病，可能对糖皮质激素治疗有反应。治疗期间SACE的降低可视为“可抑制”的SACE部分，代表由肉芽肿或其细胞前体产生的那部分酶。糖皮质激素抑制后剩余的水平可视为“基础”SACE，可能与血管内皮中产生SACE的细胞的正常更新有关。
