LeBel M, Paone R P, Lewis G P
Drug Intell Clin Pharm. 1983 Dec;17(12):908-10. doi: 10.1177/106002808301701211.
Several cephalosporins falsely elevate creatinine concentration as determined by the Jaffé reaction. We studied the in vitro effect of various concentrations of cefoperazone, ceftizoxime, ceftriaxone, ceftazidime, and azthreonam on the creatinine determination in serum, using both a manual and an automated technique. No false elevation or change in baseline creatinine concentration could be observed with any of the five antibiotics. With the use of large concentrations in serum of these beta-lactam antibiotics, we can estimate their lack of interference with creatinine determination in urine as well. Therefore, there is no need to relate the timing of blood (and urine) sampling for creatinine assay to dosage of these antibiotics.
几种头孢菌素通过杰氏反应会错误地升高肌酐浓度。我们使用手动和自动技术，研究了不同浓度的头孢哌酮、头孢唑肟、头孢曲松、头孢他啶和氨曲南对血清中肌酐测定的体外影响。这五种抗生素均未观察到肌酐浓度的基线出现错误升高或变化。在血清中使用高浓度的这些β-内酰胺类抗生素时，我们也可以估计它们对尿液中肌酐测定没有干扰。因此，进行肌酐测定时，无需将血液（和尿液）采样时间与这些抗生素的剂量相关联。
