人脂肪细胞膜微粒体对肾上腺素敏感的腺苷酸环化酶。GTP对酶活性的调节。
Epinephrine-sensitive adenylate cyclase of human fat cell ghosts. Modulation of enzyme activity by GTP.
作者信息
Kather H, Zöllig K, Simon B
出版信息
Horm Metab Res. 1978 Jan;10(1):46-9. doi: 10.1055/s-0028-1093479.
PMID:631737
Abstract
Some of the effects of GTP on human fat cell adenylate cyclase activity were studied. This nucleotide caused a dose-dependent inhibition of basal activity without affecting the hormone-activated rate of cAMP formation. Maximal effects were observed at GTP-concentrations of about 1 x 10(-4) M. The relative extent of hormonal stimulation was about 1.5-fold increased in the presence of 0.1 mM GTP.
摘要
研究了鸟苷三磷酸（GTP）对人脂肪细胞腺苷酸环化酶活性的一些影响。这种核苷酸引起基础活性的剂量依赖性抑制，而不影响环磷酸腺苷（cAMP）形成的激素激活速率。在GTP浓度约为1×10⁻⁴ M时观察到最大效应。在存在0.1 mM GTP的情况下，激素刺激的相对程度增加了约1.5倍。
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