大鼠肾脏中哌唑嗪结合位点的放射自显影定位
Autoradiographic localization of prazosin binding sites in rat kidney.
作者信息
Dashwood M R
出版信息
Eur J Pharmacol. 1983 Oct 14;94(1-2):163-6. doi: 10.1016/0014-2999(83)90456-9.
PMID:6317399
Abstract
[3H]Prazosin is a selective ligand for alpha 1-adrenoceptors. Using an in vitro autoradiographic technique specific binding of [3H]prazosin has been demonstrated, mainly to the renal cortex of the rat. These results provide further evidence that, in the rat, there is a high density of alpha 1-adrenoceptors within the renal cortex.
摘要
[3H]哌唑嗪是α1肾上腺素能受体的选择性配体。采用体外放射自显影技术已证实[3H]哌唑嗪存在特异性结合，主要位于大鼠肾皮质。这些结果进一步证明，在大鼠肾皮质中存在高密度的α1肾上腺素能受体。
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