氨中毒与超极化突触后抑制

Ammonia intoxication and hyperpolarizing postsynaptic inhibition.

作者信息

Raabe W, Lin S

出版信息

Exp Neurol. 1983 Dec;82(3):711-5. doi: 10.1016/0014-4886(83)90093-6.

Abstract

Systemic ammonia intoxication abolished the hyperpolarizing action of postsynaptic inhibition in the CNS at tissue concentrations of NH+4 which are sufficient to produce the earliest signs of encephalopathy. Therefore, the action of NH+4 on hyperpolarizing postsynaptic inhibition has to be considered as the cause, or as a contributing cause, of the encephalopathy due to systemic ammonia intoxication.

摘要

全身性氨中毒在中枢神经系统中，当铵离子（NH₄⁺）的组织浓度足以产生脑病的最早迹象时，会消除突触后抑制的超极化作用。因此，铵离子（NH₄⁺）对超极化突触后抑制的作用必须被视为全身性氨中毒所致脑病的原因或促成因素。