Hughes S M
FEBS Lett. 1983 Nov 28;164(1):1-8. doi: 10.1016/0014-5793(83)80006-4.
Proteins which bind guanine nucleotides are found in a diverse set of key regulatory positions. They are involved in hormone action, visual transduction, protein synthesis and microtubule assembly. In addition to their ability to bind guanine nucleotides these proteins possess several other common features. (i) They all have similar subunit composition, (ii) they can be ADP-ribosylated, (iii) their conformation changes depending on the nucleotide bound. These regulatory G-proteins have close functional homologies. Do they form a general class of regulatory proteins, like the protein kinases? Do they have a common evolutionary ancestry?
结合鸟嘌呤核苷酸的蛋白质存在于各种关键的调控位置。它们参与激素作用、视觉转导、蛋白质合成和微管组装。除了结合鸟嘌呤核苷酸的能力外，这些蛋白质还具有其他几个共同特征。（i）它们都具有相似的亚基组成，（ii）它们可以被ADP-核糖基化，（iii）它们的构象根据结合的核苷酸而变化。这些调节性G蛋白具有密切的功能同源性。它们是否像蛋白激酶一样形成一类通用的调节蛋白？它们是否有共同的进化起源？
