Suzuki F, Kato K, Nakajima T
J Biochem. 1983 Nov;94(5):1707-10.
When rat epididymal fat-pad pieces were incubated in vitro with 10 microM epinephrine, S-100 protein in the tissue was markedly decreased by release into the medium. The release of adipose S-100 protein was also enhanced by norepinephrine (10 microM), isoproterenol (10 microM), and dibutyryl cyclic AMP (5 mM), but not by insulin (0.8 microM). The enhancement of S-100 protein release by 10 microM epinephrine was completely inhibited by 10 microM propranolol. These results suggest that the release of adipose S-100 protein is regulated by the beta-adrenergic effect of catecholamines.
当大鼠附睾脂肪垫组织块在体外与10微摩尔肾上腺素一起孵育时，组织中的S-100蛋白会因释放到培养基中而显著减少。去甲肾上腺素（10微摩尔）、异丙肾上腺素（10微摩尔）和二丁酰环磷腺苷（5毫摩尔）也能增强脂肪组织中S-100蛋白的释放，但胰岛素（0.8微摩尔）则无此作用。10微摩尔普萘洛尔可完全抑制10微摩尔肾上腺素对S-100蛋白释放的增强作用。这些结果表明，脂肪组织中S-100蛋白的释放受儿茶酚胺的β-肾上腺素能效应调节。
