Gordon D T, Besch-Williford C, Ellersieck M R
J Nutr. 1983 Dec;113(12):2545-56. doi: 10.1093/jn/113.12.2545.
The effect of 0, 5, 10 and 20% cellulose on the apparent absorption of P, Ca, Mg, Fe, Zn and Cu were measured in balance trials, and the entire intestinal tracts of the rats were examined histologically after 23 days on the test diets. Growth and food consumption were not significantly different among groups. Mg and Zn absorption were significantly lower (P less than 0.01) in animals consuming 10 and 20% cellulose compared with animals ingesting 0 or 5% cellulose in their diets. No animals was in negative balance for any element. With increasing dietary cellulose levels, higher numbers of neutrophils and more mitotic activity were observed in crypt epithelial cells, especially of the duodenum and jejunum. However, the intestinal tracts of all animals were described as essentially normal. Lower Mg absorption at high cellulose levels was suggestive of decreased mucosal contact due to decreased intestinal transit time. The decrease in Zn utilization may arise from altered crypt and/or villous epithelial cell biochemical activity.
在平衡试验中测定了0%、5%、10%和20%纤维素对磷、钙、镁、铁、锌和铜表观吸收的影响，并在试验日粮喂养23天后对大鼠的整个肠道进行了组织学检查。各组之间的生长和食物消耗没有显著差异。与日粮中摄入0%或5%纤维素的动物相比，摄入10%和20%纤维素的动物体内镁和锌的吸收显著降低（P<0.01）。没有动物出现任何元素的负平衡。随着日粮纤维素水平的增加，在隐窝上皮细胞中观察到更多的中性粒细胞和更多的有丝分裂活性，尤其是十二指肠和空肠。然而，所有动物的肠道均被描述为基本正常。高纤维素水平下镁吸收降低提示由于肠道转运时间缩短导致黏膜接触减少。锌利用率的降低可能源于隐窝和/或绒毛上皮细胞生化活性的改变。
