Dirks P, Freeman H J
Clin Invest Med. 1987 Jan;10(1):32-8.
The effects of increasing amounts of differing single-fiber sources in chemically-defined and nutritionally-equivalent diets on morphometric measurements of the rat small and large intestinal mucosa were examined. Male Wistar rats received a fiber-free diet, or diets containing 4.5% or 9.0% cellulose, pectin, or hemicellulose. Cellulose and pectin increased jejunal (but not ileal) villus and crypt heights, whereas hemicellulose increased ileal (but not jejunal) mucosal height. Moreover, cellulose and pectin (but not hemicellulose) increased crypt heights in cecum and proximal (but not distal) colon. Parallel increases in the mitotic index were seen with cellulose and pectin diets, but there was a decrease with hemicellulose, suggesting different mechanisms for altered patterns of cell renewal induced by orally-administered single-fiber sources. These changes indicate that differing single-fiber sources exert differential structural effects along the length of the small and large intestine in the rat.
研究了在化学成分明确且营养等效的饮食中增加不同单纤维来源的量对大鼠小肠和大肠黏膜形态测量的影响。雄性Wistar大鼠接受无纤维饮食，或含有4.5%或9.0%纤维素、果胶或半纤维素的饮食。纤维素和果胶增加了空肠（而非回肠）绒毛和隐窝高度，而半纤维素增加了回肠（而非空肠）黏膜高度。此外，纤维素和果胶（而非半纤维素）增加了盲肠和近端（而非远端）结肠的隐窝高度。纤维素和果胶饮食组的有丝分裂指数平行增加，但半纤维素饮食组则降低，这表明口服单纤维来源诱导的细胞更新模式改变存在不同机制。这些变化表明，不同的单纤维来源对大鼠小肠和大肠的不同部位产生不同的结构影响。
