Lee A E
J Natl Cancer Inst. 1983 Dec;71(6):1265-9.
The responses of mammary glands of ovariectomized mice to 17 beta-estradiol and progesterone were measured by mitotic and [3H]thymidine-labeled indices in low-tumor C57BL mice and high-tumor BR6 mice. The BR6 mice were subdivided into those carrying murine mammary tumor virus (MuMTV) and those that had been freed from it by foster nursing. In all groups, continuous stimulation by the two hormones administered together resulted in a cell proliferation peak. The magnitude of response varied according to strain and the presence or absence of MuMTV. The maximal effect was seen in BR6 mice carrying the virus. Comparison of percentage of labeled mitoses curves showed that the duration of DNA synthesis was extended in BR6 mice with MuMTV, although not sufficiently to account for the observed differences in labeling indices. The responses to 17 beta-estradiol and progesterone administered separately also varied. Mice carrying the virus were more susceptible to stimulation by progesterone, whereas those without the virus responded more to 17 beta-estradiol. The results suggested that the proliferative response of the mouse mammary gland to ovarian hormones can be modified by mammary tumor virus infection.
通过有丝分裂和[3H]胸腺嘧啶核苷标记指数，在低肿瘤发生率的C57BL小鼠和高肿瘤发生率的BR6小鼠中测量了去卵巢小鼠乳腺对17β-雌二醇和孕酮的反应。BR6小鼠被细分为携带鼠乳腺肿瘤病毒（MuMTV）的小鼠和通过寄养哺乳已摆脱该病毒的小鼠。在所有组中，两种激素共同持续刺激导致细胞增殖高峰。反应的程度因品系以及MuMTV的有无而异。在携带病毒的BR6小鼠中观察到最大效应。标记有丝分裂曲线百分比的比较表明，携带MuMTV的BR6小鼠中DNA合成的持续时间延长，尽管延长程度不足以解释观察到的标记指数差异。对单独给予的17β-雌二醇和孕酮的反应也有所不同。携带病毒的小鼠对孕酮刺激更敏感，而没有病毒的小鼠对17β-雌二醇反应更强。结果表明，乳腺肿瘤病毒感染可改变小鼠乳腺对卵巢激素的增殖反应。
