Dickenson Anthony
Division of Neurophysiology and Neuropharmacology, National Institute for Medical Research, Mill Hill, London NW7 IAA Great Britain.
Pain. 1983 Nov;17(3):213-224. doi: 10.1016/0304-3959(83)90094-5.
Single unit recordings were made in the lumbar dorsal horn of the halothane anaesthetized rat. Trains of electrical stimuli applied to the ipsilateral and contralateral ventrobasal thalamic complex could powerfully inhibit the activities of both convergent cells and neurones responding only to noxious inputs. Other neuronal classes were not influenced by the stimulation. The noxious and tactile related activities of the convergent cells were reduced by the thalamic stimulation. Electrolytic lesions of nucleus raphe magnus markedly reduced the inhibitory influences. The relevance of these effects to the analgesic effects of thalamic stimulation in man and animals is discussed.
在氟烷麻醉的大鼠腰段背角进行单单位记录。施加于同侧和对侧腹基丘脑复合体的电刺激串可强烈抑制会聚细胞和仅对伤害性输入有反应的神经元的活动。其他神经元类别不受该刺激影响。丘脑刺激可降低会聚细胞的伤害性和触觉相关活动。中缝大核的电解损伤显著降低了这种抑制作用。讨论了这些效应与丘脑刺激在人和动物中的镇痛作用的相关性。
