Tsilinskiĭ Ia Ia, Karpova E F
Vopr Virusol. 1983 Sep-Oct;28(5):601-7.
A natural process of infection with multiploid virions was stimulated and the genetic effects occurring in this infection were studied in experiments with homogeneous attenuated strain of Venezuelan equine encephalomyelitis virus producing the smallest plaques. The process of infection with multiploid virions was reproduced by infecting the cells with artificially obtained aggregates. Under these conditions, small- and large-plaque virus was produced which in some cases had a higher virulence than the parental strain. A possible mechanism of this phenomenon and its practical implications for the evaluation of the properties of attenuated alphavirus strains is discussed.
刺激了多倍体病毒粒子的自然感染过程，并在使用产生最小噬斑的委内瑞拉马脑炎病毒同源减毒株的实验中研究了这种感染中发生的遗传效应。通过用人工获得的聚集体感染细胞来重现多倍体病毒粒子的感染过程。在这些条件下，产生了小噬斑和大噬斑病毒，在某些情况下，它们的毒力高于亲本菌株。讨论了这种现象的可能机制及其对评估减毒甲病毒株特性的实际意义。
