Reddehase M J, Keil G M, Koszinowski U H
Eur J Immunol. 1984 Jan;14(1):56-61. doi: 10.1002/eji.1830140111.
During the acute cytolytic T lymphocyte (CTL) response of mice to infection with the murine cytomegalovirus two independent populations of activated interleukin-receptive CTL precursors can be demonstrated. One population is specific for cell membrane-incorporated viral structural antigens, whereas the second population detects an antigen, whose appearance is correlated with the synthesis of viral immediate early proteins. Since this new type of antigen is only defined by lymphocyte recognition, it is referred to as the lymphocyte-detected immediate early antigen (LYDIEA). Expression of immediate early antigen precedes the production of viral progeny and, therefore, it is possible that LYDIEA-specific CTL could serve as indicator cells for the very first activities of the viral genome, even during nonproductive infection.
在小鼠对鼠巨细胞病毒感染的急性细胞溶解性T淋巴细胞（CTL）应答过程中，可以证明存在两个独立的活化白细胞介素受体CTL前体细胞群体。一个群体对细胞膜结合的病毒结构抗原具有特异性，而第二个群体检测到一种抗原，其出现与病毒立即早期蛋白的合成相关。由于这种新型抗原仅通过淋巴细胞识别来定义，因此被称为淋巴细胞检测到的立即早期抗原（LYDIEA）。立即早期抗原的表达先于病毒子代的产生，因此，即使在非生产性感染期间，LYDIEA特异性CTL也有可能作为病毒基因组最初活动的指示细胞。
