Watanabe Y, Shibuya T, Salafsky B, Hill H F
Eur J Pharmacol. 1983 Dec 9;96(1-2):141-4. doi: 10.1016/0014-2999(83)90542-3.
The effects of chronic perinatal or postnatal administrations of diazepam on opiate receptor development in cerebral cortex and striatum were studied at two different post-treatment ages, using tritiated ethylketocyclazocine, the prototypic kappa-opiate, for measurements of opiate binding site ontogeny. Prenatal plus postnatal exposure to diazepam markedly decreased the total number of binding sites for [3H]ethylketocyclazocine in the rat cerebral cortex and striatum at 14 days of age. Postnatal diazepam treatment alone did not alter [3H]ethylketocyclazocine binding site development in cortex or striatum. These results suggest that development of opiate receptors in rat brain can be altered by prenatal exposure to diazepam.
使用氚标记的原型κ阿片类药物乙基酮环唑辛，研究了围产期或产后长期给予地西泮对两个不同治疗后年龄大鼠大脑皮质和纹状体阿片受体发育的影响，以测量阿片结合位点的个体发生。产前加产后暴露于地西泮显著降低了14日龄大鼠大脑皮质和纹状体中[3H]乙基酮环唑辛结合位点的总数。单独产后给予地西泮并未改变皮质或纹状体中[3H]乙基酮环唑辛结合位点的发育。这些结果表明，产前暴露于地西泮可改变大鼠脑中阿片受体的发育。
