Lymangrover J R, Keku E
Life Sci. 1984 Jan 23;34(4):371-7. doi: 10.1016/0024-3205(84)90626-x.
A variety of effects of A23187 have been reported as its actions on adrenocortical steroidogenesis. This diversity probably resulted because of differences in the protocol of applying the Ca++ ionophore. We continue to observe a dose-dependent potentiation by the ionophore on ACTH-stimulated corticosterone secretory activity of superfused rat adrenocortical slices. This effect was eliminated or reversed if the tissue was pretreated with A23187 for 30 min prior to secretagogue application. The quality of the ionophore effect also depends on the submaximal dose of ACTH employed.
据报道，A23187对肾上腺皮质类固醇生成有多种作用。这种多样性可能是由于应用钙离子载体的方案不同所致。我们继续观察到该离子载体对超灌注大鼠肾上腺皮质切片促肾上腺皮质激素（ACTH）刺激的皮质酮分泌活性具有剂量依赖性增强作用。如果在应用促分泌剂之前，将组织用A23187预处理30分钟，这种作用就会消除或逆转。离子载体作用的性质还取决于所使用的ACTH亚最大剂量。
