Venter J C, Eddy B, Schaber J S, Lilly L, Fraser C M
Prog Clin Biol Res. 1983;135:183-206.
These data indicate a number of similarities between the neurotransmitter receptors of different pharmacological classes. We are pursuing the hypothesis that the neurotransmitter receptors may have evolved from one another and contain constant regions (eg, adenylate cyclase and calcium channel interaction sites) and variable regions (eg, neurotransmitter- or hormone-binding sites). It is clear that monoclonal antibodies are keys to this end.
这些数据表明不同药理学类别的神经递质受体之间存在一些相似之处。我们正在探究这样一种假说，即神经递质受体可能是由彼此演化而来的，并且包含恒定区域（例如，腺苷酸环化酶和钙通道相互作用位点）和可变区域（例如，神经递质或激素结合位点）。显然，单克隆抗体是实现这一目标的关键。
