Houpt T R
Physiol Behav. 1983 Nov;31(5):693-8. doi: 10.1016/s0031-9384(83)80005-5.
The synthetic octapeptide of cholecystokinin (CCK-8) was infused at the rate of 67 ng/kg-minute into the jugular vein, carotid artery, portal vein, gastric branch of the splenic artery, and aortic artery both craniad and caudad to the origins of the cranial mesenteric and coeliac arteries of 39 young female pigs. Jugular, carotid and cranial erotic infusions resulted in significant reduction of meal size respectively to 65, 67 and 71% of control meal size (p less than 0.05). Gastric artery infusion resulted in a significant increase of meal size to 122% of control meal size (p less than 0.05). Portal vein and caudal aortic artery infusions had no significant effects on meal size. The results were interpreted as indicating a major site of action of CCK in reducing meal size in the bed of the cranial mesenteric or coeliac arteries, but excluding the stomach and liver.
将合成的胆囊收缩素八肽（CCK - 8）以67纳克/千克·分钟的速率注入39只年轻雌性猪的颈静脉、颈动脉、门静脉、脾动脉胃支以及肠系膜上动脉和腹腔动脉起始部头侧和尾侧的主动脉。颈静脉、颈动脉和头侧主动脉注入分别使进食量显著减少至对照进食量的65%、67%和71%（p<0.05）。胃动脉注入使进食量显著增加至对照进食量的122%（p<0.05）。门静脉和尾侧主动脉注入对进食量无显著影响。结果表明，CCK减少进食量的主要作用部位在肠系膜上动脉或腹腔动脉床，但不包括胃和肝脏。
