Yerevanian B I, Woolf P D, Iker H P
Psychiatry Res. 1983 Nov;10(3):175-81. doi: 10.1016/0165-1781(83)90053-7.
Sixteen patients with major depressive disorder who were nonsuppressors on the dexamethasone suppression test (DST) on hospital admission were studied for plasma levels of adrenocorticotropic hormone (ACTH). Eight patients reverted to normal suppression with clinical recovery, while eight remained nonsuppressors. There was a significant reduction of ACTH levels in those who normalized on their DST, while ACTH levels remained high in the group that continued to be nonsuppressors. The results favored the hypothesis that dexamethasone nonsuppression in depression is mediated by high ACTH levels.
对16例入院时地塞米松抑制试验（DST）结果为不被抑制的重度抑郁症患者进行促肾上腺皮质激素（ACTH）血浆水平研究。8例患者随着临床症状恢复，DST结果恢复正常抑制，而另外8例仍为不被抑制。DST结果恢复正常的患者ACTH水平显著降低，而持续不被抑制的患者ACTH水平仍维持在高位。这些结果支持了抑郁症患者地塞米松不被抑制是由高ACTH水平介导的这一假说。
