DeVito W J, Brush F R
Behav Neurosci. 1984 Feb;98(1):59-71. doi: 10.1037//0735-7044.98.1.59.
These experiments demonstrated that both ACTH and arginine vasopressin (AVP) delay the extinction of a shuttle box avoidance response in intact rats. Furthermore, the effect of ACTH (2.5 IU) and AVP (0.2 IU) on extinction was the same when these hormones were administered daily throughout the course of extinction testing. Doses of naloxone, which did not affect this behavior, differentially blocked the effects of these hormones, ACTH being more easily blocked than AVP. The results are interpreted in terms of opiate mediation of the effects of the hormones and do not support the assertion that ACTH works through motivation whereas vasopressin works through memory.
这些实验表明，促肾上腺皮质激素（ACTH）和精氨酸加压素（AVP）均可延缓正常大鼠穿梭箱回避反应的消退。此外，在整个消退测试过程中每日给予促肾上腺皮质激素（2.5国际单位）和精氨酸加压素（0.2国际单位）时，它们对消退的影响相同。不影响该行为的纳洛酮剂量可不同程度地阻断这些激素的作用，促肾上腺皮质激素比精氨酸加压素更容易被阻断。这些结果是根据激素作用的阿片介导来解释的，并不支持促肾上腺皮质激素通过动机起作用而加压素通过记忆起作用的说法。
