EDTA对肾刷状缘膜中ADP核糖基转移酶的刺激机制。
Mechanism of stimulation of ADP-ribosyltransferase in the renal brush-border membrane by EDTA.
作者信息
Kempson S A
出版信息
Biochim Biophys Acta. 1984 Feb 29;770(1):101-4. doi: 10.1016/0005-2736(84)90079-8.
PMID:6320880
Abstract
In the presence of NAD+, renal brush-border membranes are mono-ADP-ribosylated by an endogenous ADP-ribosyltransferase. The reaction is inhibited by arginine methyl ester and is markedly stimulated by EDTA. Stimulation by EDTA is likely due, at least in part, to EDTA preventing the destruction of intact NAD+ by other enzymes in the brush-border membrane.
摘要
在烟酰胺腺嘌呤二核苷酸（NAD⁺）存在的情况下，肾刷状缘膜会被一种内源性ADP核糖基转移酶单ADP核糖基化。该反应受到精氨酸甲酯的抑制，并被乙二胺四乙酸（EDTA）显著刺激。EDTA的刺激作用可能至少部分是由于它能防止刷状缘膜中的其他酶破坏完整的NAD⁺。
Zotero 插件