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不同温度驯化的仓鼠棕色脂肪组织中线粒体“解偶联”蛋白浓度的适应性变化。

Adaptive changes in the concentration of the mitochondrial 'uncoupling' protein in brown adipose tissue of hamsters acclimated at different temperatures.

作者信息

Trayhurn P, Richard D, Jennings G, Ashwell M

出版信息

Biosci Rep. 1983 Dec;3(12):1077-84. doi: 10.1007/BF01120199.

DOI:10.1007/BF01120199
PMID:6320922
Abstract

The effect of acclimation at different temperatures on the activity of interscapular brown adipose tissue has been investigated in the hamster, a hibernator. Between 31 degrees and 4 degrees C the cytochrome oxidase activity of the tissue increased 4- to 5-fold, mitochondrial GDP binding per mg of mitochondrial protein doubled, and the amount of uncoupling protein rose from 1.7% to 5.4% of total mitochondrial protein. It is concluded that there are clear adaptive changes induced by temperature in brown adipose tissue of the hamster, but the changes are limited in comparison with those in the mouse.

摘要

在冬眠动物仓鼠身上,研究了在不同温度下驯化对肩胛间棕色脂肪组织活性的影响。在31摄氏度至4摄氏度之间,该组织的细胞色素氧化酶活性增加了4至5倍,每毫克线粒体蛋白的线粒体GDP结合量增加了一倍,解偶联蛋白的量从线粒体总蛋白的1.7%升至5.4%。得出的结论是,仓鼠棕色脂肪组织中存在由温度诱导的明显适应性变化,但与小鼠相比,这些变化是有限的。

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