Buchweitz E, Grandison L, Weiss H R
Brain Res. 1984 Jan 23;291(2):301-8. doi: 10.1016/0006-8993(84)91262-9.
The effects of acute opiate receptor stimulation on regional cerebral oxygen consumption and blood flow were examined in 9 regions of the artificially respired, alpha-chloralose-anesthetized cat. Regional cerebral arterial and venous oxygen saturation were examined microspectrophotometrically and regional cerebral blood flow was monitored using radioactively tagged microspheres (15 +/- 3 micron in diameter). Oxygen consumption was calculated as the product of flow and oxygen extraction. In 8 cats, after control cerebral blood flow was obtained, and in 8 experimental cats after this same measurement was obtained before and 40 min after the administration of 1.5 mg/kg morphine sulfate; the cats' heads were simultaneously sawed in 3 places and quickly frozen in liquid nitrogen-cooled propane. Systolic and diastolic blood pressure were significantly decreased by treatment. The heterogeneity of venous oxygen saturation was significantly reduced by morphine. Average cerebral blood flow, oxygen extraction and consumption were not altered significantly by morphine. Regional cerebral blood flow in the hypothalamus, thalamic oxygen extraction, and hypothalamic and thalamic oxygen consumption were significantly decreased by treatment. This low dose of morphine may produce changes in cerebral neuronal and/or synthetic activity which lowers oxygen consumption in some regions rich in opiate receptors, while not affecting overall brain oxygen supply or consumption.
在人工呼吸、用α-氯醛糖麻醉的猫的9个脑区，研究了急性阿片受体刺激对局部脑氧消耗和血流的影响。用显微分光光度法检测局部脑动脉和静脉血氧饱和度，并用放射性标记微球（直径15±3微米）监测局部脑血流。氧消耗计算为血流量与氧摄取量的乘积。在8只猫中，在获得对照脑血流后，以及在8只实验猫中，在静脉注射1.5mg/kg硫酸吗啡之前和之后40分钟进行相同测量后，将猫的头部同时在3个部位锯开，并迅速在液氮冷却的丙烷中冷冻。治疗后收缩压和舒张压显著降低。吗啡显著降低了静脉血氧饱和度的异质性。吗啡对平均脑血流量、氧摄取和消耗没有显著影响。治疗后下丘脑局部脑血流量、丘脑氧摄取以及下丘脑和丘脑氧消耗显著降低。这种低剂量吗啡可能会引起脑神经元和/或合成活动的变化，从而降低某些富含阿片受体区域的氧消耗，而不影响脑的整体氧供应或消耗。
