Szafarczyk A, Pelzer E, Ixart G, Malaval F, Nouguier-Soulé J, Assenmacher I
C R Seances Acad Sci III. 1983;297(9):471-6.
The possible effects of pinealectomy on the corticotropic system was studied in either sighted or ocular enucleated adult female Rats. Individual ACTH and corticosterone measurements were performed on sequential plasma samples obtained over a 48 hrs period from a carotid implanted cannula. Compared with their respective sighted or blind controls, pinealectomized Rats displayed no alteration in the hormonal rhythms' periodicity, phase, mean level and amplitude. On the other hand, ocular enucleation, whether or not associated with pinealectomy depressed the amplitude and to a lesser extent the mean level of the ACTH rhythm, and paradoxically increased the corticosterone rhythm's mean level. While no pineal factors appear therefore required for a normal corticotropic rhythmicity, the possible regulating role of retinal melatonin may be discussed.
在有视力或已摘除眼球的成年雌性大鼠中，研究了松果体切除对促肾上腺皮质激素系统的可能影响。通过植入颈动脉的插管，在48小时内连续采集血浆样本，对个体促肾上腺皮质激素（ACTH）和皮质酮进行测量。与各自有视力或失明的对照组相比，松果体切除的大鼠在激素节律的周期性、相位、平均水平和幅度方面没有变化。另一方面，眼球摘除，无论是否与松果体切除相关，都会降低ACTH节律的幅度，并在较小程度上降低其平均水平，而反常地增加皮质酮节律的平均水平。因此，虽然正常的促肾上腺皮质激素节律似乎不需要松果体因子，但视网膜褪黑素的可能调节作用值得探讨。
