Anderson L M, Priest L J, Deschner E E, Budinger J M
Cancer Lett. 1983 Sep;20(2):117-23. doi: 10.1016/0304-3835(83)90039-3.
Benzo[a]pyrene (BP) was administered intracolonically to ICR/Ha and C57Bl/6 female mice, 1 mg/mouse, once weekly for 14 weeks. Half of the mice received beta-naphthoflavone (beta-NF, a mixed-function oxygenase inducer) i.p. 24 h prior to the BP. No colonic neoplasms were found in any of the mice after 18 months. However, the BP treatment did cause a significant increase in numbers of primary lung tumors, forestomach papillomas, mammary carcinomas, and sarcomas in one or both strains, relative to controls, and the incidence of all of these except for the sarcomas was significantly reduced by treatment with beta-NF prior to BP. Overall, the beta-NF pretreatment reduced total incidence of neoplasms by about 30% in the ICR/Ha mice and by about 60% in the C57Bl/6 mice, and did not potentiate the action of the carcinogen in any organ.
将苯并[a]芘（BP）以1毫克/只小鼠的剂量经结肠内给予ICR/Ha和C57Bl/6雌性小鼠，每周一次，共14周。一半的小鼠在给予BP前24小时腹腔注射β-萘黄酮（β-NF，一种混合功能氧化酶诱导剂）。18个月后，在任何一只小鼠中均未发现结肠肿瘤。然而，相对于对照组，BP处理确实导致一种或两种品系的原发性肺肿瘤、前胃乳头瘤、乳腺癌和肉瘤数量显著增加，并且除肉瘤外，所有这些肿瘤的发生率在用β-NF预处理后均显著降低。总体而言，β-NF预处理使ICR/Ha小鼠的肿瘤总发生率降低了约30%，使C57Bl/6小鼠的肿瘤总发生率降低了约60%，并且在任何器官中均未增强致癌物的作用。
