二氧化硅处理大鼠中的副球孢子菌病

Paracoccidioidomycosis in silica-treated rats.

作者信息

Kerr I B, Da Costa S C, Schaffer G V, Lagrange P H

出版信息

Immunol Lett. 1983;7(3):129-33. doi: 10.1016/0165-2478(83)90058-5.

Abstract

An attempt is made to evaluate the importance of macrophages in the early local reaction to infection caused by the fungus Paracoccidioides brasiliensis. With this purpose, an attempt was made to impair macrophagic activity in the site of the fungal inoculum, by means of previous injections of silica. Twenty male rats were intraperitoneally infected with yeast cells of the fungus. Ten of the rats were injected intraperitoneally with silica particles twice, namely 24 and 4 h before the infection. All the animals were killed 4 wk after fungal inoculum. The results showed that the disease was aggravated in rats pre-treated with silica, clearly demonstrated by the 100% metastatic pulmonary involvement, in contrast with only 40% observed in the non-treated controls.

摘要

旨在评估巨噬细胞在对巴西副球孢子菌引起的感染的早期局部反应中的重要性。为此，通过预先注射二氧化硅来尝试损害真菌接种部位的巨噬细胞活性。二十只雄性大鼠经腹腔感染该真菌的酵母细胞。其中十只大鼠在感染前24小时和4小时经腹腔注射二氧化硅颗粒两次。所有动物在接种真菌4周后处死。结果显示，预先用二氧化硅处理的大鼠病情加重，100%的肺转移受累清楚地证明了这一点，相比之下，未处理的对照组中仅观察到40%。