Kerr I B, Schaeffer G V, Miranda D S
Mycopathologia. 1984 Dec 30;88(2-3):149-54. doi: 10.1007/BF00436446.
The development of intraperitoneal paracoccidioidomycosis was studied in groups of female and male rats: a) Under normal conditions (intacts), b) After castration and c) After castration but submitted to a treatment with, respectively, testosterone and estradiol. The criterion of susceptibility to infection was based on: 1) Spontaneous mortality of the animals and 2) Number of metastatic pulmonary lesions. The results showed that: the unique deaths and the more severe pulmonary lesions were found among the intact females, representing the animals most susceptible to the infection in these experiments; the intact females showed more numerous lesions than the castrated; the intact males had less lesions than the castrated, and than those castrated which were treated with estradiol.
a）在正常条件下（未处理），b）阉割后，以及c）阉割后分别接受睾酮和雌二醇治疗。感染易感性标准基于：1）动物的自然死亡率和2）转移性肺部病变的数量。结果表明：在未处理的雌性大鼠中发现了唯一的死亡病例和更严重的肺部病变，这表明在这些实验中这些动物对感染最易感；未处理的雌性大鼠的病变比阉割后的更多；未处理的雄性大鼠的病变比阉割后的少，也比接受雌二醇治疗的阉割大鼠少。
