Koo A, Liang I Y
J Appl Physiol Respir Environ Exerc Physiol. 1978 Feb;44(2):190-4. doi: 10.1152/jappl.1978.44.2.190.
The microcirculation of the spinotrapezius muscle in normal and cold-acclimated (4 degrees C) rats was observed by an in vivo microscopic technique. The responses of the arterioles and venules in the skeletal muscle microcirculation to topical application of norepinephrine (NE) were recorded by a photomicrographic method. Results show that the skeletal muscle microcirculation possesses both alpha- and beta-adrenergic vascular receptors. Stimulation of the alpha-receptor results in vasoconstriction, and of the beta-receptor, vasodilatation. These microvascular responses are antagonized by specific alpha- and beta-adrenergic blockers. Cold-acclimation (4 degrees C) for 3 wk decreases the responses of the skeletal muscle microvessels to NE stimulation. This diminished sensitivity is due to an attenuation of the alpha-adrenergic receptor mechanism.
采用体内显微技术观察正常及冷适应（4℃）大鼠斜方肌的微循环。通过显微摄影法记录骨骼肌微循环中微动脉和微静脉对局部应用去甲肾上腺素（NE）的反应。结果表明，骨骼肌微循环同时具有α和β肾上腺素能血管受体。刺激α受体导致血管收缩，刺激β受体则导致血管舒张。这些微血管反应可被特异性α和β肾上腺素能阻滞剂拮抗。3周的冷适应（4℃）可降低骨骼肌微血管对NE刺激的反应。这种敏感性降低是由于α肾上腺素能受体机制的减弱。
