Katovich M J, Baker S P, Nelson C
Life Sci. 1984 Feb 27;34(9):889-98. doi: 10.1016/0024-3205(84)90206-6.
Subcutaneous inoculation of the prolactin secreting MtTW15 adenoma in male Wistar Furth rats for 4 weeks produced a significant increase in serum prolactin and a corresponding decrease in peripheral beta-adrenergic responsiveness. Both the isoproterenol induced drink and heart rate responses used to assess the beta-adrenergic responsiveness were significantly reduced in the hyperprolactinemic rat. Serum T3 and T4 levels were measured as was cardiac beta-adrenergic receptor number to ascertain if an alteration of thyroid hormone and a resultant decrease in beta-adrenergic receptor number was responsible for the attenuated beta-adrenergic responsiveness. Serum T4 was significantly reduced in the hyperprolactinemic group (1.9 +/- 0.3 microgram%) as compared to the control group (6.4 +/- 0.l5 microgram%). However there was no significant difference in serum T3 or in cardiac beta-adrenergic receptor number between the two groups. Removal of the MtTW15 adenoma resulted in a normalization of serum prolactin, T4, and in the responsiveness of the peripheral beta-adrenergic system within 4-6 weeks. These results indicate that the attenuated beta-adrenergic responsiveness associated with hyperprolactinemia is reversible and not dependent on a reduction in beta-adrenergic receptor number.
在雄性Wistar Furth大鼠皮下接种分泌催乳素的MtTW15腺瘤4周，导致血清催乳素显著升高，外周β-肾上腺素能反应性相应降低。用于评估β-肾上腺素能反应性的异丙肾上腺素诱导的饮水和心率反应在高催乳素血症大鼠中均显著降低。测量血清T3和T4水平以及心脏β-肾上腺素能受体数量，以确定甲状腺激素的改变以及由此导致的β-肾上腺素能受体数量减少是否是β-肾上腺素能反应性减弱的原因。与对照组（6.4±0.15微克%）相比，高催乳素血症组血清T4显著降低（1.9±0.3微克%）。然而，两组之间血清T3或心脏β-肾上腺素能受体数量没有显著差异。切除MtTW15腺瘤导致血清催乳素、T4以及外周β-肾上腺素能系统反应性在4-6周内恢复正常。这些结果表明，与高催乳素血症相关的β-肾上腺素能反应性减弱是可逆的，且不依赖于β-肾上腺素能受体数量的减少。
