躁狂抑郁症的钠钾ATP酶假说。I. 一般考虑因素。

The Na,K-ATPase hypothesis for manic-depression. I. General considerations.

作者信息

el-Mallakh R S

出版信息

Med Hypotheses. 1983 Nov;12(3):253-68. doi: 10.1016/0306-9877(83)90042-7.

PMID:6321918

Abstract

An hypothesis is presented to explain and integrate experimental and clinical observations on manic-depressive (bipolar or biphasic) psychosis. The model is based on alterations in the activity of the sodium, potassium-activated adenosine triphosphatase (Na, K-ATPase) pump. A reduction in the activity of the Na,K-ATPase can be responsible for both phases of the disorder.

摘要

本文提出了一个假说，以解释和整合关于躁狂抑郁症（双相或双相型）精神病的实验和临床观察结果。该模型基于钠钾激活的三磷酸腺苷酶（Na，K-ATP酶）泵活性的改变。Na，K-ATP酶活性降低可能是该疾病两个阶段的病因。