对锂有反应的躁郁症患者红细胞膜中的钠钾、镁和钙ATP酶活性

Sodium-potassium, magnesium, and calcium ATPase activities in erythrocyte membranes from manic-depressive patients responding to lithium.

作者信息

Alexander D R, Deeb M, Bitar F, Antun F

出版信息

Biol Psychiatry. 1986 Sep;21(11):997-1007. doi: 10.1016/0006-3223(86)90280-5.

Abstract

Erythrocyte membrane Na+-K+ adenosine triphosphatase (ATPase), Mg2+ ATPase, and Ca2+ ATPase activities were compared among 23 euthymic manic-depressive patients responding to lithium therapy and 24 healthy controls. The two groups were similar in age, sex composition, body mass index, and community background. No significant differences were noted in mean ATPase activities between the two groups. However, plasma lithium concentration correlated positively with Na+-K+ ATPase and Mg2+ ATPase activities within the patient group, and six patients with plasma lithium levels in the range of 0.85-1.2 mM had Na+-K+ ATPase activities 62% greater than the control group mean. Possible biochemical mechanisms for the effects of lithium therapy on erythrocyte membrane functions are discussed.

摘要

比较了23名对锂治疗有反应的心境正常的躁郁症患者和24名健康对照者的红细胞膜钠钾腺苷三磷酸酶（ATP酶）、镁ATP酶和钙ATP酶活性。两组在年龄、性别构成、体重指数和社区背景方面相似。两组之间的平均ATP酶活性没有显著差异。然而，患者组中血浆锂浓度与钠钾ATP酶和镁ATP酶活性呈正相关，6名血浆锂水平在0.85 - 1.2 mM范围内的患者的钠钾ATP酶活性比对照组平均值高62%。讨论了锂治疗对红细胞膜功能影响的可能生化机制。