Ehrengut W, AgRhaly A, Koch I, Koumaré B, Simaga S Y, Diallo D
Monatsschr Kinderheilkd. 1984 Jan;132(1):29-31.
118 infants under 3 years of age were thrice orally immunised against poliomyelitis at 2 months interval. Before the vaccination 26% were triple negative and 24% triple positive. 44% had neutralising polio antibodies type 1, 53% type 2 and 52% type 3. At the end of the vaccinations 59% of the vaccinees were triple positive and only 3.4% triple negative. 82% had polio antibodies type 1, 85% antibodies type 2 and 76% antibodies type 3. At the start of the trial 54% of the vaccinees excreted enteroviruses. Only in 12% young infants had enterovirus in anal swabs and seroconverted well. In view of the prevalence of paralytic poliomyelitis in tiny babies an early oral polio immunisation in the tropics is highly recommended.
118名3岁以下婴儿每隔2个月口服脊髓灰质炎疫苗进行三次免疫。接种疫苗前，26%为三项阴性，24%为三项阳性。44%有1型脊髓灰质炎中和抗体，53%有2型中和抗体，52%有3型中和抗体。接种疫苗结束时，59%的接种者三项呈阳性，只有3.4%三项呈阴性。82%有1型脊髓灰质炎抗体，85%有2型抗体，76%有3型抗体。试验开始时，54%的接种者排出肠道病毒。只有12%的幼儿肛门拭子中有肠道病毒且血清转化良好。鉴于热带地区小婴儿中麻痹性脊髓灰质炎的流行情况，强烈建议在热带地区尽早口服脊髓灰质炎疫苗。
