[摩洛哥营养不良儿童脊髓灰质炎和麻疹疫苗接种反应评估]

[Evaluation of the response to vaccination against poliomyelitis and measles in malnourished children in Morocco].

作者信息

Caidi H, Bennis I F, Mouan N, El Aouad R

机构信息

Département d'Immuno-Virologie, Institut national d'Hygiène, Rabat, Maroc.

出版信息

East Mediterr Health J. 2004 Jul-Sep;10(4-5):474-81.

PMID:16335637

Abstract

We made a comparative survey of the poliovirus antibodies (anti-poliovirus type 1, anti-poliovirus type 2 and anti-poliovirus type 3) and the measles antibodies in malnourished but completely vaccinated children (37) and control children (34). The age range was 10 months to 5 years. Immunization in children with protein-energy malnutrition was low for both vaccines. Seroprevalence rates of the polio 1, polio 2, polio 3 antibodies and the measles antibodies in the control group were 94.1%, 97.1%, 91.2% and 82.4% respectively. In malnourished children the respective rates were in some cases significantly lower being: 40.5% (P = 0.001), 59.5% (P = 0.001), 40.5% and 35.1%. Malnutrition is a major determinant of the humoral response to oral polio and measles vaccines and must be given due consideration to prevent vaccination failure.

摘要

我们对营养不良但已完全接种疫苗的儿童（37名）和对照儿童（34名）的脊髓灰质炎病毒抗体（抗1型脊髓灰质炎病毒、抗2型脊髓灰质炎病毒和抗3型脊髓灰质炎病毒）及麻疹抗体进行了比较调查。年龄范围为10个月至5岁。两种疫苗在蛋白质 - 能量营养不良儿童中的免疫接种率都很低。对照组中1型脊髓灰质炎、2型脊髓灰质炎、3型脊髓灰质炎抗体及麻疹抗体的血清阳性率分别为94.1%、97.1%、91.2%和82.4%。在营养不良儿童中，相应的比率在某些情况下显著较低，分别为：40.5%（P = 0.001）、59.5%（P = 0.001）、40.5%和35.1%。营养不良是影响口服脊髓灰质炎疫苗和麻疹疫苗体液免疫反应的主要决定因素，必须予以充分考虑以防止疫苗接种失败。