Mostov K E, Friedlander M, Blobel G
Nature. 1984;308(5954):37-43. doi: 10.1038/308037a0.
We have cloned and sequenced cDNA for the receptor that mediates the endocytosis and transcellular transport of IgA and IgM across many glandular epithelia into external secretions. This receptor contains five extracellular domains which are strikingly homologous to each other and to immunoglobulin variable regions.
我们已经克隆并测序了介导IgA和IgM通过许多腺上皮细胞进行胞吞作用和跨细胞转运至外分泌液中的受体的cDNA。该受体含有五个细胞外结构域,它们彼此之间以及与免疫球蛋白可变区显著同源。