缓激肽、组胺以及白三烯B4、C4和D4对仓鼠肺中6-酮-前列腺素F1α和血栓素B2形成的影响。

The effect of bradykinin, histamine, and leukotrienes B4, C4 and D4 on the formation of 6-keto-prostaglandin F1 alpha and thromboxane B2 in hamster lungs.

作者信息

Puustinen T, Uotila P

出版信息

Prostaglandins Leukot Med. 1983 Dec;12(4):443-8. doi: 10.1016/0262-1746(83)90035-5.

Abstract

Bradykinin, histamine, leukotriene B4, C4, D4 (LTB4, LTC4, LTD4), and bradykinin + LTC4 were injected as a bolus into the pulmonary circulation of hamster isolated lungs, and the amounts of 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha) and thromboxane B2 (TXB2) in the perfusion effluent were determined by radioimmunoassay. LTD4, bradykinin, and bradykinin + LTC4 stimulated 6-keto-PGF1 alpha formation whereas TXB2 formation was stimulated only by LTB4 and histamine. The detected changes in the activation of arachidonate metabolism were, however, relatively small. The present study indicates that bradykinin, histamine, LTB4, and LTD4 have only a minor stimulating effect on arachidonic acid metabolism in hamster lungs.

摘要

将缓激肽、组胺、白三烯B4、C4、D4（LTB4、LTC4、LTD4）以及缓激肽 + LTC4以大剂量注入离体仓鼠肺的肺循环中，通过放射免疫分析法测定灌注流出液中6 - 酮 - 前列腺素F1α（6 - 酮 - PGF1α）和血栓素B2（TXB2）的含量。LTD4、缓激肽以及缓激肽 + LTC4刺激6 - 酮 - PGF1α的生成，而仅LTB4和组胺刺激TXB2的生成。然而，所检测到的花生四烯酸代谢激活的变化相对较小。本研究表明，缓激肽、组胺、LTB4和LTD4对仓鼠肺中花生四烯酸代谢仅有轻微的刺激作用。