Whitescarver S A, Ott C E, Jackson B A, Guthrie G P, Kotchen T A
Science. 1984 Mar 30;223(4643):1430-2. doi: 10.1126/science.6322303.
The effect of the anion associated with sodium loading on the development of hypertension in the Dahl salt-sensitive rat was determined. For 5 weeks rats were fed a diet containing normal or high concentrations of sodium chloride or high concentrations of sodium provided as a mixture of sodium bicarbonate, phosphate, and amino acids. After 1 week on these diets and until the end of the study the rats receiving high concentrations of sodium chloride had higher systolic blood pressures than the rats in the other two groups. There were no statistically significant group differences in plasma volume, arterial pH, or plasma concentrations of Na+, K+, Cl-, Ca2+, or creatinine, or in renomedullary prostaglandin E2 production. Compared to the animals receiving normal concentrations of sodium chloride, those receiving high concentrations of sodium chloride or amino acids showed decreased plasma renin activity and plasma aldosterone concentrations. Thus, the anion ingested with sodium alters the development and severity of hypertension in the Dahl salt-sensitive rat.
研究了与钠负荷相关的阴离子对Dahl盐敏感大鼠高血压发展的影响。给大鼠喂食含正常或高浓度氯化钠的饮食，或喂食以碳酸氢钠、磷酸盐和氨基酸混合物形式提供的高浓度钠饮食，持续5周。在这些饮食喂养1周后直至研究结束，接受高浓度氯化钠的大鼠收缩压高于其他两组大鼠。在血浆容量、动脉pH值、血浆中Na+、K+、Cl-、Ca2+或肌酐的浓度，或肾髓质前列腺素E2的产生方面，各组之间无统计学显著差异。与接受正常浓度氯化钠的动物相比，接受高浓度氯化钠或氨基酸的动物血浆肾素活性和血浆醛固酮浓度降低。因此，与钠一同摄入的阴离子会改变Dahl盐敏感大鼠高血压的发展和严重程度。
