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[一名肾功能不全女性患者的氢碲源性氟骨症。关于一例组织形态计量学分析的病例]

[Fluoride osteosis of hydro-telluric origin in a female patient with renal insufficiency. Apropos of a case with histomorphometric analysis].

作者信息

Hurault de Ligny B, Gilson B, Mariot A, Kessler M, Arlot A, Meunier P J, Huriet C

出版信息

Sem Hop. 1984 Jan 19;60(2):119-23.

PMID:6322326
Abstract

We report a case of fluorosis due to high water and soil contents in a 23-year-old Algerian woman. The condition, which is infrequent at this age, was promoted by chronic renal failure due to a congenital renal malformation. Roentgenograms showing osteosis with increased bone density were suggestive of fluorosis rather than renal osteodystrophy. Bone tissue fluoride assay confirmed fluorosis. Histomorphometric analysis of bone biopsy specimens showed mixed lesions: major osteocondensation due to bone fluorosis and morphologic and dynamic osteomalacia related to the chronic renal failure.

摘要

我们报告了一例23岁阿尔及利亚女性因水和土壤中氟含量高而导致氟中毒的病例。这种情况在这个年龄段并不常见,是由先天性肾畸形导致的慢性肾衰竭引发的。X线片显示骨质密度增加的骨病,提示为氟中毒而非肾性骨营养不良。骨组织氟含量测定证实为氟中毒。骨活检标本的组织形态计量学分析显示有混合性病变:主要是由于骨氟中毒导致的骨硬化,以及与慢性肾衰竭相关的形态学和动态性骨软化。

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