[从患有脊髓灰质炎临床表现的患者中分离肠道病毒]

[Isolation of enteroviruses from patients with clinical manifestations of poliomyelitis].

作者信息

Spynu K I, Vutkarev V P

出版信息

Vopr Virusol. 1983 Nov-Dec;28(6):686-9.

Abstract

Examinations of 114 specimens (feces, nasopharyngeal washings, cerebrospinal fluid) from patients with clinical manifestations of poliomyelitis were carried out. Enteroviruses were isolated in 61.4% of the cases. Among the isolates, poliomyelitis viruses accounted for 49.1%, and Coxsackie B1 and ECHO 6 12.3%. Typing of the poliovirus isolates showed 17.9% to belong to type I, 7.1% to type II, and 75% to type III. Studies on intratypic differentiation revealed their antigenic similarity with the Mahoney, MEF-1, and Saukett strains, respectively. Among 24 paired blood sera tested for virus-neutralizing antibodies to wild poliovirus strains 21 demonstrated a 4-fold or higher rise of antibody titres to the above poliomyelitis viruses.

摘要

对114份来自有脊髓灰质炎临床表现患者的标本（粪便、鼻咽冲洗液、脑脊液）进行了检测。61.4%的病例中分离出肠道病毒。在分离出的病毒中，脊髓灰质炎病毒占49.1%，柯萨奇B1病毒和埃可6型病毒占12.3%。脊髓灰质炎病毒分离株的分型显示，17.9%属于I型，7.1%属于II型，75%属于III型。型内分化研究表明，它们分别与马奥尼、MEF - 1和索基特毒株具有抗原相似性。在检测针对野生脊髓灰质炎病毒株的病毒中和抗体的24对血清中，21对显示出针对上述脊髓灰质炎病毒的抗体滴度有4倍或更高的升高。