Kelleher J F, Luban N L, Cohen B J, Mortimer P P
Am J Dis Child. 1984 Apr;138(4):401-3. doi: 10.1001/archpedi.1984.02140420067020.
An infectious agent has long been suspected as the cause of aplastic crisis in sickle cell disease, but no specific organism has been implicated. We studied six children with sickle cell disease in whom an aplastic crisis developed, looking for evidence of parvoviruslike virus (SPLV) infection using a new radioimmunoassay. All six patients had conclusive evidence of acute infection with SPLV. We postulated that SPLV is the predominant cause of aplastic crises in patients with hemolytic anemia.
长期以来，人们一直怀疑感染因子是镰状细胞病再生障碍危象的病因，但尚未明确具体是哪种微生物。我们研究了6例发生再生障碍危象的镰状细胞病患儿，采用一种新的放射免疫测定法寻找细小病毒样病毒（SPLV）感染的证据。所有6例患者均有SPLV急性感染的确凿证据。我们推测SPLV是溶血性贫血患者再生障碍危象的主要病因。
