Forouhar F A, Quinn J J, Cooke R, Foster J H
Arch Pathol Lab Med. 1984 Apr;108(4):311-4.
A 15-month-old girl had a case of mixed hepatoblastoma. The unresectable tumor became surgically resectable after treatment with doxorubicin hydrochloride and cisplatin, which was also continued postoperatively. This regimen had a remarkable necrotizing effect on the fetal epithelial component of the hepatoblastoma. The patient's high alpha-fetoprotein level and extreme thrombocytosis, which resolved with treatment, were used as indicators of the disease's activity. An unaffected mesenchymal component and a few microscopic foci of undisturbed embryonal hepatoblastoma were found. The finding of a mature intestinal epithelial island in this case is unique.
一名15个月大的女童患有混合型肝母细胞瘤。经盐酸多柔比星和顺铂治疗后，原本无法切除的肿瘤变得可以手术切除，术后也继续使用该方案治疗。该方案对肝母细胞瘤的胎儿上皮成分有显著的坏死作用。患者治疗前较高的甲胎蛋白水平和极度血小板增多症在治疗后得到缓解，被用作疾病活动的指标。发现有未受影响的间充质成分以及一些未受干扰的胚胎性肝母细胞瘤的微小病灶。该病例中发现成熟的肠上皮岛是独一无二的。
