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单核吞噬细胞特异性生长因子CSF-1在细胞表面与它的受体发生化学交联。

Chemical crosslinking of the mononuclear phagocyte specific growth factor CSF-1 to its receptor at the cell surface.

作者信息

Morgan C J, Stanley E R

出版信息

Biochem Biophys Res Commun. 1984 Feb 29;119(1):35-41. doi: 10.1016/0006-291x(84)91614-0.

DOI:10.1016/0006-291x(84)91614-0
PMID:6322783
Abstract

The cell surface receptor for CSF-1 has been identified by affinity labeling intact mouse bone marrow-derived macrophages and intact cells of the murine J774.2 and BAC1 lines, which differ in their specific CSF-1 binding capacities and biological responses. The receptor, labeled by crosslinking to 125I-CSF-1 with disuccinimidyl suberate, is a polypeptide of approximately 165,000 molecular weight, irrespective of cell type.

摘要

通过亲和标记完整的小鼠骨髓来源巨噬细胞以及小鼠J774.2和BAC1细胞系的完整细胞，已鉴定出CSF-1的细胞表面受体，这两种细胞系在其特异性CSF-1结合能力和生物学反应方面存在差异。该受体通过与辛二酸二琥珀酰亚胺酯交联到125I-CSF-1上进行标记，无论细胞类型如何，它都是一种分子量约为165,000的多肽。

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