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1
Effect of histrionicotoxin on ion channels in synaptic and conducting membranes of electroplax of Electrophorus electricus.组织毒素对电鳗电板突触膜和传导膜中离子通道的影响。
Cell Mol Neurobiol. 1983 Sep;3(3):203-12. doi: 10.1007/BF00710947.
2
Effect of batrachotoxin on the electroplax of electric eel: evidence for voltage-dependent interaction with sodium channels.蟾毒素对电鳗电板的作用：与钠通道电压依赖性相互作用的证据。
Proc Natl Acad Sci U S A. 1977 Mar;74(3):951-5. doi: 10.1073/pnas.74.3.951.
3
Isolation of membrane fractions with sodium channels sensitive to veratridine and tetrodotoxin from the electric organ of the eel Electrophorus electricus.从电鳗电鳐的电器官中分离出对藜芦碱和河豚毒素敏感的具有钠通道的膜组分。
J Neurochem. 1987 Mar;48(3):846-52. doi: 10.1111/j.1471-4159.1987.tb05594.x.
4
Binding of [3H]perhydrohistrionicotoxin and [3H]phencyclidine to the nicotinic receptor-ion channel complex of Torpedo electroplax. Inhibition by histrionicotoxins and derivatives.[3H]全氢组氨毒碱和[3H]苯环利定与电鳐电器官烟碱受体-离子通道复合物的结合。组氨毒碱及其衍生物的抑制作用。
Biochem Pharmacol. 1985 Sep 1;34(17):3037-47. doi: 10.1016/0006-2952(85)90145-5.
5
Single-channel properties of the reconstituted voltage-regulated Na channel isolated from the electroplax of Electrophorus electricus.从电鳗电板分离出的重组电压门控钠通道的单通道特性。
Proc Natl Acad Sci U S A. 1984 Sep;81(17):5594-8. doi: 10.1073/pnas.81.17.5594.
6
Purified and unpurified sodium channels from eel electroplax in planar lipid bilayers.来自电鳗电板的纯化和未纯化的钠通道在平面脂质双分子层中的情况。
J Gen Physiol. 1987 Sep;90(3):375-95. doi: 10.1085/jgp.90.3.375.
7
Reconstituted voltage-sensitive sodium channel from Electrophorus electricus: chemical modifications that alter regulation of ion permeability.来自电鳗的重组电压敏感钠通道：改变离子通透性调节的化学修饰。
Proc Natl Acad Sci U S A. 1987 Sep;84(17):6282-6. doi: 10.1073/pnas.84.17.6282.
8
Activation, inactivation, and desensitization of acetylcholine receptor channel complex detected by binding of perhydrohistrionicotoxin.通过全氢组胺毒素结合检测乙酰胆碱受体通道复合物的激活、失活和脱敏
Proc Natl Acad Sci U S A. 1980 Apr;77(4):2309-13. doi: 10.1073/pnas.77.4.2309.
9
Fluorescence assay for neurotoxin-modulated ion transport by the reconstituted voltage-activated sodium channel isolated from eel electric organ.利用从电鳗电器官分离出的重组电压门控钠通道对神经毒素调节的离子转运进行荧光测定。
Biochemistry. 1986 Apr 22;25(8):2162-74. doi: 10.1021/bi00356a047.
10
Reconstitution of neurotoxin-modulated ion transport by the voltage-regulated sodium channel isolated from the electroplax of Electrophorus electricus.从电鳗（Electrophorus electricus）电板分离出的电压调节钠通道对神经毒素调节的离子转运的重构。
Proc Natl Acad Sci U S A. 1984 Feb;81(4):1239-43. doi: 10.1073/pnas.81.4.1239.

本文引用的文献

1
The active structure of local anesthetics. Effects on electrical and cholinesterase activity.局部麻醉药的活性结构。对电活动和胆碱酯酶活性的影响。
Biochim Biophys Acta. 1963 May 21;66:406-14. doi: 10.1016/0006-3002(63)91209-5.
2
An isolated single electroplax preparation. I. New data on the effect of acetylcholine and related compounds.一种分离的单个电鱼放电器官标本。I. 关于乙酰胆碱及相关化合物作用的新数据。
Biochim Biophys Acta. 1957 Oct;26(1):1-15. doi: 10.1016/0006-3002(57)90047-1.
3
Stabilization of the high affinity state of the membrane-bound acetylcholine receptor from Torpedo marmorata by noncompetitive-blockers. Evidence for dual interaction and pharmacological selectivity.用非竞争性阻滞剂稳定电鳐膜结合型乙酰胆碱受体的高亲和力状态。双重相互作用和药理学选择性的证据。
FEBS Lett. 1981 Aug 31;131(2):239-44. doi: 10.1016/0014-5793(81)80375-4.
4
Ultraviolet light-induced labeling by noncompetitive blockers of the acetylcholine receptor from Torpedo marmorata.用非竞争性阻滞剂对斑纹电鳐乙酰胆碱受体进行紫外线诱导标记。
Proc Natl Acad Sci U S A. 1981 Jun;78(6):3925-9. doi: 10.1073/pnas.78.6.3925.
5
Batrachotoxin-induced depolarization and [3H]batrachotoxinin-a 20 alpha-benzoate binding in a vesicular preparation from guinea pig cerebral cortex.在豚鼠大脑皮层囊泡制剂中，蛙毒素诱导的去极化作用及[3H]蛙毒素A 20α-苯甲酸酯结合。
Mol Pharmacol. 1983 Mar;23(2):350-8.
6
The effect of yohimbine on sodium and gating currents in frog Ranvier node membrane.育亨宾对青蛙郎飞结膜中钠电流和门控电流的影响。
Neuroscience. 1982 Jun;7(6):1377-87. doi: 10.1016/0306-4522(82)90251-2.
7
Actions of the histrionicotoxins at the ion channel of the nicotinic acetylcholine receptor and at the voltage-sensitive ion channels of muscle membranes.
Mol Pharmacol. 1982 Mar;21(2):351-61.
8
Mechanism of nicotinic channel activation and blockade.烟碱型通道激活与阻断的机制。
Ann N Y Acad Sci. 1980;358:204-38. doi: 10.1111/j.1749-6632.1980.tb15397.x.
9
Ion channels and membrane potential in stimulus-secretion coupling in adrenal medulla cells.肾上腺髓质细胞刺激-分泌偶联中的离子通道与膜电位
J Neurochem. 1981 Mar;36(3):1245-55. doi: 10.1111/j.1471-4159.1981.tb01724.x.
10
Activation, inactivation, and desensitization of acetylcholine receptor channel complex detected by binding of perhydrohistrionicotoxin.通过全氢组胺毒素结合检测乙酰胆碱受体通道复合物的激活、失活和脱敏
Proc Natl Acad Sci U S A. 1980 Apr;77(4):2309-13. doi: 10.1073/pnas.77.4.2309.

组织毒素对电鳗电板突触膜和传导膜中离子通道的影响。

Effect of histrionicotoxin on ion channels in synaptic and conducting membranes of electroplax of Electrophorus electricus.

作者信息

Bartels-Bernal E, Diaz E, Cadena R, Ramos J, Daly J W

出版信息

Cell Mol Neurobiol. 1983 Sep;3(3):203-12. doi: 10.1007/BF00710947.

DOI:10.1007/BF00710947
PMID:6322994
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11572860/
Abstract

Histrionicotoxin (HTX) at low concentrations of 5-10 microM blocks the postsynaptic potential of the electroplax of Electrophorus electricus. At 100-fold higher concentrations, HTX blocks the directly evoked action potentials of the conducting membrane. The pH dependence of the blockade by HTX at synaptic channels is different from that at the conducting membrane. At the synapse HTX is more potent at acid pH, while at the conducting membrane it is more potent at basic pH. HTX at high concentrations antagonizes the effects of batrachotoxin, indicative of an effect on the batrachotoxin-sensitive sodium channels involved in action potential generation. While the effects of HTX on the synaptic channels are concentration, time, and pH dependent, the effects on the channels of the conducting membrane are, in addition, use dependent, suggesting interactions of HTX with the activated forms of these channels.

摘要

低浓度（5 - 10微摩尔）的组胺毒素（HTX）可阻断电鳗电板的突触后电位。在浓度高出100倍时，HTX可阻断传导膜的直接诱发动作电位。HTX在突触通道处的阻断作用对pH的依赖性与在传导膜处不同。在突触处，HTX在酸性pH条件下更有效，而在传导膜处，它在碱性pH条件下更有效。高浓度的HTX可拮抗蛙毒素的作用，表明其对参与动作电位产生的蛙毒素敏感钠通道有影响。虽然HTX对突触通道的作用取决于浓度、时间和pH，但对传导膜通道的作用还取决于使用情况，这表明HTX与这些通道的活化形式存在相互作用。