Putney J W
Cell Calcium. 1983 Dec;4(5-6):439-49. doi: 10.1016/0143-4160(83)90020-9.
In the rat parotid salivary gland, fluid secretion is regulated by alterations in fluxes of monovalent ions. In vitro, stimulation of muscarinic, alpha-adrenergic or substance P receptors provokes a biphasic increase in membrane permeability to K+ which can be conveniently assayed as efflux of 86Rb. The increased 86Rb flux is thought to arise in response to a receptor mediated elevation in [Ca2+]i which activates Ca2+-activated K+-channels. The biphasic nature of the response is presumably due to a biphasic mode of Ca2+ mobilization by secretagogues; a transient response reflects release of a finite pool of Ca from an intracellular store while a more sustained phase results from Ca entry through receptor operated Ca channels or gates. Calcium also mediates an increased Na+ entry which in turn activates the Na+, K+-pump. The mechanism involved in the regulation of monovalent ion channels by Ca2+ is not understood.
在大鼠腮腺唾液腺中，液体分泌受单价离子通量变化的调节。在体外，刺激毒蕈碱、α - 肾上腺素能或P物质受体可引起膜对K⁺通透性的双相增加，这可以通过⁸⁶Rb外流方便地测定。⁸⁶Rb通量增加被认为是由于受体介导的细胞内钙离子浓度（[Ca²⁺]i）升高，从而激活了钙激活钾通道。这种反应的双相性质可能是由于促分泌剂动员钙离子的双相模式所致；短暂反应反映了细胞内储存池中有限的钙离子释放，而更持久的阶段则是由于钙离子通过受体操纵的钙通道或门进入细胞所致。钙离子还介导了钠离子进入增加，进而激活钠钾泵。钙离子调节单价离子通道的机制尚不清楚。
