腮腺腺泡碎片中胆碱能刺激的磷脂酰肌醇分解与离子环境无关。
Cholinergically stimulated phosphatidylinositol breakdown in parotid-gland fragments is independent of the ionic environment.
作者信息
Jones L M, Michell R H
出版信息
Biochem J. 1976 Aug 15;158(2):505-7. doi: 10.1042/bj1580505.
Abstract
Carbamoylcholine stimulated phosphatidylinositol breakdown in rat parotid-gland fragments incubated in either a Krebs--Ringer medium or an ion-depleted iso-osmotic sucrose medium. This suggest that phosphatidylinositol breakdown is not initiated by a change in the intracellular concentration of Na+ or of K+, and previous experiments have already indicated that it is independent of cyclic nucleotides and Ca2+. Thus it seems that this reaction may be initiated by a direct interaction at the plasma membrane between the activated muscarinic cholinergic receptor system and the enzyme that catalyses phosphatidylinositol breakdown.
摘要
在 Krebs-Ringer 培养基或离子缺失的等渗蔗糖培养基中孵育的大鼠腮腺腺泡碎片，氨甲酰胆碱可刺激其磷脂酰肌醇的分解。这表明磷脂酰肌醇的分解不是由细胞内 Na⁺ 或 K⁺ 浓度的变化引发的，并且先前的实验已经表明它与环核苷酸和 Ca²⁺ 无关。因此，似乎该反应可能是由活化的毒蕈碱胆碱能受体系统与催化磷脂酰肌醇分解的酶在质膜上的直接相互作用引发的。
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本文引用的文献
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J Biol Chem. 1973 Jan 10;248(1):369-72.
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Endocrinology. 1974 Dec;95(6):1529-33. doi: 10.1210/endo-95-6-1529.
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Breakdown of phosphatidylinositol provoked by muscarinic cholinergic stimulation of rat parotid-gland fragments.毒蕈碱型胆碱能刺激大鼠腮腺碎片引发的磷脂酰肌醇分解
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