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1
Cholinergically stimulated phosphatidylinositol breakdown in parotid-gland fragments is independent of the ionic environment.腮腺腺泡碎片中胆碱能刺激的磷脂酰肌醇分解与离子环境无关。
Biochem J. 1976 Aug 15;158(2):505-7. doi: 10.1042/bj1580505.
2
Lanthanum as a tool to study the role of phosphatidylinositol in the calcium transport in rat parotid glands upon cholinergic stimulation.
Eur J Biochem. 1978 Apr;85(1):77-83. doi: 10.1111/j.1432-1033.1978.tb12213.x.
3
Phosphoinositide breakdown in isolated rat parotid membranes. Stimulation by cholinergic and alpha-adrenergic agonists.分离的大鼠腮腺膜中的磷酸肌醇分解。胆碱能和α-肾上腺素能激动剂的刺激作用。
FEBS Lett. 1984 Dec 10;178(2):278-82. doi: 10.1016/0014-5793(84)80616-x.
4
The relationship of calcium to receptor-controlled stimulation of phosphatidylinositol turnover. Effects of acetylcholine, adrenaline, calcium ions, cinchocaine and a bivalent cation ionophore on rat parotid-gland fragments.钙与受体控制的磷脂酰肌醇代谢刺激之间的关系。乙酰胆碱、肾上腺素、钙离子、辛可卡因和一种二价阳离子离子载体对大鼠腮腺组织块的影响。
Biochem J. 1975 Jun;148(3):479-85. doi: 10.1042/bj1480479.
5
Activation by calcium of membrane channels for potassium in exocrine gland cells.外分泌腺细胞中钾离子膜通道的钙激活作用。
Cell Calcium. 1983 Dec;4(5-6):439-49. doi: 10.1016/0143-4160(83)90020-9.
6
Sympathetic denervation impairs agonist-stimulated phosphatidylinositol metabolism in rat parotid glands.交感神经去神经支配会损害大鼠腮腺中激动剂刺激的磷脂酰肌醇代谢。
Biochem J. 1983 Sep 15;214(3):865-70. doi: 10.1042/bj2140865.
7
Lithium-induced reduction in intracellular inositol supply in cholinergically stimulated parotid gland.锂诱导的胆碱能刺激的腮腺细胞内肌醇供应减少。
Biochem J. 1986 Feb 15;234(1):199-204. doi: 10.1042/bj2340199.
8
Extracellular ATP increases free cytosolic calcium in rat parotid acinar cells. Differences from phospholipase C-linked receptor agonists.细胞外ATP可增加大鼠腮腺腺泡细胞胞质内的游离钙。与磷脂酶C偶联受体激动剂的差异。
Biochem J. 1988 Oct 1;255(1):291-300.
9
Breakdown of polyphosphoinositides and not phosphatidylinositol accounts for muscarinic agonist-stimulated inositol phospholipid metabolism in rat parotid glands.多磷酸肌醇而非磷脂酰肌醇的分解代谢是毒蕈碱激动剂刺激大鼠腮腺中肌醇磷脂代谢的原因。
Biochem J. 1983 Dec 15;216(3):633-40. doi: 10.1042/bj2160633.
10
Inositol 1,2-cyclic 4,5-trisphosphate is not a product of muscarinic receptor-stimulated phosphatidylinositol 4,5-bisphosphate hydrolysis in rat parotid glands.肌醇1,2-环4,5-三磷酸不是毒蕈碱受体刺激大鼠腮腺中磷脂酰肌醇4,5-二磷酸水解的产物。
Biochem J. 1987 Apr 1;243(1):211-8. doi: 10.1042/bj2430211.

引用本文的文献

1
Regulation of phosphatidate synthesis by secretagogues in parotid acinar cells.腮腺腺泡细胞中促分泌素对磷脂酸合成的调节。
Biochem J. 1982 May 15;204(2):587-92. doi: 10.1042/bj2040587.
2
Role of Na+/Ca2+ exchange and the plasma membrane Ca2+ pump in hormone-mediated Ca2+ efflux from pancreatic acini.
J Membr Biol. 1988 May;102(2):153-62. doi: 10.1007/BF01870453.
3
The receptor-regulated calcium influx in mouse submandibular acinar cells is sodium dependent: a patch-clamp study.小鼠下颌下腺腺泡细胞中受体调节的钙内流依赖于钠：一项膜片钳研究。
J Physiol. 1987 Mar;384:119-30. doi: 10.1113/jphysiol.1987.sp016446.
4
Investigation of the relationship between cell-surface calcium-ion gating and phosphatidylinositol turnover by comparison of the effects of elevated extracellular potassium ion concentration on ileium smooth muscle and pancreas.通过比较细胞外钾离子浓度升高对回肠平滑肌和胰腺的影响，研究细胞表面钙离子门控与磷脂酰肌醇代谢之间的关系。
Biochem J. 1976 Nov 15;160(2):397-9. doi: 10.1042/bj1600397.
5
A comparison of the effects of phytohaemagglutinin and of calcium ionophore A23187 on the metabolism of glycerolipids in small lymphocytes.植物血凝素与钙离子载体A23187对小淋巴细胞甘油脂质代谢影响的比较
Biochem J. 1977 May 15;164(2):389-97. doi: 10.1042/bj1640389.
6
Phosphatidylinositol metabolism in rat hepatocytes stimulated by glycogenolytic hormones. Effects of angiotensin, vasopressin, adrenaline, ionophore A23187 and calcium-ion deprivation.糖原分解激素刺激大鼠肝细胞中的磷脂酰肌醇代谢。血管紧张素、血管加压素、肾上腺素、离子载体A23187和钙离子剥夺的影响。
Biochem J. 1979 Sep 15;182(3):661-8. doi: 10.1042/bj1820661.
7
Stimulation of phosphatidylinositol turnover in various tissues by cholinergic and adrenergic agonists, by histamine and by caerulein.胆碱能和肾上腺素能激动剂、组胺及蛙皮素对各种组织中磷脂酰肌醇代谢的刺激作用。
Biochem J. 1979 Sep 15;182(3):669-76. doi: 10.1042/bj1820669.

本文引用的文献

1
Calcium and energy requirements for K + release mediated by the epinephrine -receptor in rat parotid slices.大鼠腮腺切片中肾上腺素受体介导的钾离子释放所需的钙和能量
J Biol Chem. 1973 Jan 10;248(1):369-72.
2
The role of Na+ and K+ in the stimulation by thyrotropin of phospholipid turnover in bovine thyroid slices.钠和钾在促甲状腺激素刺激牛甲状腺切片中磷脂周转过程中的作用。
Endocrinology. 1974 Dec;95(6):1529-33. doi: 10.1210/endo-95-6-1529.
3
Breakdown of phosphatidylinositol provoked by muscarinic cholinergic stimulation of rat parotid-gland fragments.毒蕈碱型胆碱能刺激大鼠腮腺碎片引发的磷脂酰肌醇分解
Biochem J. 1974 Sep;142(3):583-90. doi: 10.1042/bj1420583.
4
Enhanced phosphatidylinositol labelling in rat parotid fragments exposed to alpha-adrenergic stimulation.暴露于α-肾上腺素能刺激下的大鼠腮腺碎片中磷脂酰肌醇标记增强。
Biochem J. 1974 Jan;138(1):47-52. doi: 10.1042/bj1380047.
5
Production of 1,2-diacylglycerol and phosphatidate in human erythrocytes treated with calcium ions and ionophore A23187.钙离子和离子载体A23187处理的人红细胞中1,2 - 二酰甘油和磷脂酸的产生
Biochem J. 1976 May 15;156(2):225-32. doi: 10.1042/bj1560225.
6
Muscarinic cholinergic stimulation of phosphatidylinositol turnover in the longitudinal smooth muscle of guinea-pig ileum.毒蕈碱胆碱能刺激豚鼠回肠纵行平滑肌中磷脂酰肌醇的周转。
Biochem J. 1976 Mar 15;154(3):653-7. doi: 10.1042/bj1540653.
7
Stimulation of phosphatidylinositol turnover by histamine, 5-hydroxytryptamine and adrenaline in the longitudinal smooth muscle of guinea pig ileum.组胺、5-羟色胺和肾上腺素对豚鼠回肠纵行平滑肌中磷脂酰肌醇代谢的刺激作用。
Biochem Pharmacol. 1976 Jun 15;25(12):1429-30. doi: 10.1016/0006-2952(76)90115-5.
8
The relationship of calcium to receptor-controlled stimulation of phosphatidylinositol turnover. Effects of acetylcholine, adrenaline, calcium ions, cinchocaine and a bivalent cation ionophore on rat parotid-gland fragments.钙与受体控制的磷脂酰肌醇代谢刺激之间的关系。乙酰胆碱、肾上腺素、钙离子、辛可卡因和一种二价阳离子离子载体对大鼠腮腺组织块的影响。
Biochem J. 1975 Jun;148(3):479-85. doi: 10.1042/bj1480479.
9
Enhanced synthesis de novo of phosphatidylinositol in lymphocytes treated with cationic amphiphilic drugs.阳离子两亲性药物处理的淋巴细胞中磷脂酰肌醇从头合成增强。
Biochem J. 1975 Jun;148(3):471-8. doi: 10.1042/bj1480471.
10
Influence of potassium and calcium ions on the phosphatidylinositol and phosphatidylcholine metabolism in rat fibroblasts after growth stimulation by calf serum.
Eur J Biochem. 1975 Aug 15;56(2):413-20. doi: 10.1111/j.1432-1033.1975.tb02247.x.

腮腺腺泡碎片中胆碱能刺激的磷脂酰肌醇分解与离子环境无关。

Cholinergically stimulated phosphatidylinositol breakdown in parotid-gland fragments is independent of the ionic environment.

作者信息

Jones L M, Michell R H

出版信息

Biochem J. 1976 Aug 15;158(2):505-7. doi: 10.1042/bj1580505.

DOI:10.1042/bj1580505
PMID:985445
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1163998/
Abstract

Carbamoylcholine stimulated phosphatidylinositol breakdown in rat parotid-gland fragments incubated in either a Krebs--Ringer medium or an ion-depleted iso-osmotic sucrose medium. This suggest that phosphatidylinositol breakdown is not initiated by a change in the intracellular concentration of Na+ or of K+, and previous experiments have already indicated that it is independent of cyclic nucleotides and Ca2+. Thus it seems that this reaction may be initiated by a direct interaction at the plasma membrane between the activated muscarinic cholinergic receptor system and the enzyme that catalyses phosphatidylinositol breakdown.

摘要

在 Krebs-Ringer 培养基或离子缺失的等渗蔗糖培养基中孵育的大鼠腮腺腺泡碎片，氨甲酰胆碱可刺激其磷脂酰肌醇的分解。这表明磷脂酰肌醇的分解不是由细胞内 Na⁺ 或 K⁺ 浓度的变化引发的，并且先前的实验已经表明它与环核苷酸和 Ca²⁺ 无关。因此，似乎该反应可能是由活化的毒蕈碱胆碱能受体系统与催化磷脂酰肌醇分解的酶在质膜上的直接相互作用引发的。