Meikle A W, Worley R J, West C D
Fertil Steril. 1984 Apr;41(4):575-9.
Data are limited on the existence of adrenal hyperplasia or cortisol oversecretion in women with hirsutism. Supranormal responses of cortisol (greater than 20 micrograms/dl) were observed at 15 and 30 minutes after the 8:00 A.M. adrenocorticotropin (0.5 U) injection (performed after 1 mg of dexamethasone taken orally at midnight) in 6 of the 12 hirsute women (hirsute I) and in all 4 women with Cushing's disease. Baseline plasma levels of corticoids, androgens, and gonadotropins, body weight, menstrual history, and degree of hirsutism were all indistinguishable between the two hirsute groups. The mean plasma levels of cortisol and 17-hydroxyprogesterone were both significantly greater in the hirsute I group and in those with adrenal hyperplasia caused by Cushing's disease than in normal subjects. Our data indicate that adrenal hyperplasia is a common abnormality in women with hirsutism. We speculate that this abnormality may contribute to the pathogenesis of hirsutism and ovarian dysfunction in many hirsute women.
关于多毛症女性中肾上腺增生或皮质醇分泌过多情况的数据有限。在12名多毛症女性中的6名（多毛症I组）以及所有4名库欣病女性中，于上午8点注射促肾上腺皮质激素（0.5单位）（午夜口服1毫克地塞米松后进行）后15分钟和30分钟时观察到皮质醇超正常反应（大于20微克/分升）。两组多毛症患者的皮质类固醇、雄激素和促性腺激素的基线血浆水平、体重、月经史及多毛程度均无差异。多毛症I组及由库欣病引起肾上腺增生的患者中，皮质醇和17 - 羟孕酮的平均血浆水平均显著高于正常受试者。我们的数据表明，肾上腺增生在多毛症女性中是一种常见异常。我们推测这种异常可能在许多多毛症女性的多毛症发病机制及卵巢功能障碍中起作用。
