Patricio J, Germain M, Gremillet C, Forgacs A, Delavierre P
J Chir (Paris). 1978 Jan;115(1):39-45.
Portal hypertension was obtained by portal ligature in the rat by an original procedure. Hemodynamic and pathological studies were performed at the end of the 4th postoperative month. Portal hypertension causes macroscopic and histological lesions in particular in the stomach and small intestine. The lesions observed were superficial desquamation, interstitial oedema, submucosal fibrosis, ulcers, and superficial or total necrosis of the intestine. Splenic fibrosis with congestion of the medullary sinuses is usual. A collateral circulation towards the liver and caval system develops rapidly. We never observed oesophageal varices. The main cause of splanchnic modifications was vascular stasis to which should perhaps be added humoral changes. Highly selective vagotomy does not protect the splanchnic area against lesions induced by portal ligature.
采用一种原创方法通过门静脉结扎在大鼠中诱导门静脉高压。在术后第4个月末进行血流动力学和病理学研究。门静脉高压会导致宏观和组织学病变，尤其是在胃和小肠。观察到的病变包括表层剥脱、间质水肿、黏膜下纤维化、溃疡以及肠道的表层或全层坏死。脾纤维化伴髓窦充血较为常见。迅速形成了向肝脏和腔静脉系统的侧支循环。我们从未观察到食管静脉曲张。内脏改变的主要原因是血管淤滞，或许还应加上体液变化。高选择性迷走神经切断术并不能保护内脏区域免受门静脉结扎所致病变的影响。
