Barbara L, Corinaldesi R, Pasquali R, Raiti C, Zurita J, Stanghellini V
Int J Tissue React. 1983;5(4):387-92.
This paper reviews investigations on the endocrine effects of two H2-receptor antagonists, cimetidine and ranitidine. Cimetidine has hyperprolactinaemic properties and interferes with the peripheral activity of the sexual hormone (DHT) and probably with the pituitary LH secretion. A possible effect on TSH and thyroid hormone secretion or peripheral metabolism is suggested. Ranitidine seems to have no central or peripheral effects (after both acute and chronic administration) on sexual hormones. High doses (300 mg i.v. bolus) of the drug induce a significant increase in prolactin basal levels, whereas no effects follow oral administration. The effects on PRL are sex-related and less marked than those obtained with cimetidine. The chronic administration of this drug does not affect basal or TRH-stimulated PRL levels. No effects were apparent on TSH serum levels after either oral or i.v. acute administration, whereas lower basal and TRH-stimulated T4 values were registered after chronic treatment. On the basis of these results, a possible interference of ranitidine on iodothyronine metabolism can be suggested.
本文综述了两种H2受体拮抗剂西咪替丁和雷尼替丁的内分泌效应研究。西咪替丁具有高催乳素血症特性，会干扰性激素（双氢睾酮）的外周活性，可能还会干扰垂体促黄体生成素的分泌。提示其可能对促甲状腺激素和甲状腺激素分泌或外周代谢有影响。雷尼替丁（急性和慢性给药后）似乎对性激素没有中枢或外周效应。高剂量（静脉推注300mg）该药可使催乳素基础水平显著升高，而口服给药则无此效应。对催乳素的影响与性别有关，且不如西咪替丁明显。该药的慢性给药不影响基础或促甲状腺激素释放激素刺激的催乳素水平。口服或静脉急性给药后，血清促甲状腺激素水平均无明显影响，而慢性治疗后基础和促甲状腺激素释放激素刺激的甲状腺素值较低。基于这些结果，提示雷尼替丁可能对碘甲状腺原氨酸代谢有干扰作用。
