Furlini G, Coppolecchia P, Re M C, Baldassarri B, Ripalti A, Landini M P
J Antimicrob Chemother. 1983 Nov;12(5):503-6. doi: 10.1093/jac/12.5.503.
.5 mM of novobiocin completely suppresses the replication of human cytomegalovirus (HCMV) in vitro. Based on the evidence that murine cytomegalovirus (MCMV) titres were reduced in vitro by 60% with the same concentration of the drug, the in vivo antiviral activity of novobiocin has been tested in the murine model. The results showed that if treatment started before the infection virus was not isolated from parenchymal organs during treatment. Virus could be isolated 24 h after stopping treatment, but not from kidney or spleen.
0.5毫摩尔的新生霉素在体外能完全抑制人巨细胞病毒（HCMV）的复制。基于相同浓度的该药物在体外可使鼠巨细胞病毒（MCMV）滴度降低60%这一证据，已在鼠模型中测试了新生霉素的体内抗病毒活性。结果显示，如果在感染前开始治疗，则在治疗期间实质器官中未分离出病毒。停药24小时后可分离出病毒，但肾脏或脾脏中未分离出。
