Uylangco C, Santiago L, Pescante M, Menday P, Christensen O
J Antimicrob Chemother. 1984 Feb;13(2):171-5. doi: 10.1093/jac/13.2.171.
The comparative efficacy of antibacterial therapy with pivmecillinam or cotrimoxazole and general supportive care only was studied in patients with severe bacterial gastroenteritis. Overall, treatment with antibiotics proved significantly superior to rehydration alone in 42 children. Active therapy also had a statistically beneficial effect in children infected with Vibrio cholerae and V. parahaemolyticus. Pivmecillinam and co-trimoxazole were equally effective. Pivmecillinam and oral mecillinam appeared to be of equal value in a further 22 adults infected by Vibrio spp. No side-effects were recorded in any of the subjects treated. Further investigations with pivmecillinam and oral mecillinam are advocated.
在患有严重细菌性肠胃炎的患者中，研究了用匹美西林或复方新诺明进行抗菌治疗与仅进行一般支持性护理的疗效对比。总体而言，在42名儿童中，抗生素治疗被证明明显优于单纯补液。积极治疗对感染霍乱弧菌和副溶血性弧菌的儿童也有统计学上的有益效果。匹美西林和复方新诺明同样有效。在另外22名感染弧菌属的成年人中，匹美西林和口服美西林似乎具有同等价值。接受治疗的任何受试者均未记录到副作用。提倡对匹美西林和口服美西林进行进一步研究。
