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烧伤患者外周血T细胞数量及功能的动力学研究

Kinetics of peripheral blood T cell numbers and functions in patients with burns.

作者信息

Menon T, Sundararaj T, Subramanian S, Murugesan R, Sunderarajan C R

出版信息

J Trauma. 1984 Mar;24(3):220-3. doi: 10.1097/00005373-198403000-00006.

DOI:10.1097/00005373-198403000-00006
PMID:6323729
Abstract

Cell-mediated immunity (CMI) was assessed in 58 patients with burns involving 10% to 40% of the total body surface area (TBSA), and in 16 normal healthy individuals, by using two parameters, the total T-cell counts in peripheral circulation and T-cell function as indicated by the leukocyte migration inhibition (LMI) test. Three recall antigens from Candida albicans, S. typhi, and E. histolytica were used to elicit the LMI. T-cell function was found to be significantly depressed in burns involving more than 25% TBSA. Depression of T-cell function started after the seventh postburn (PB) day and continued until the sixtieth PB day.

摘要

通过使用外周循环中总T细胞计数和白细胞迁移抑制(LMI)试验所表明的T细胞功能这两个参数,对58名烧伤面积占全身表面积(TBSA)10%至40%的患者以及16名正常健康个体进行了细胞介导免疫(CMI)评估。使用来自白色念珠菌、伤寒沙门氏菌和溶组织内阿米巴的三种回忆抗原来引发LMI。发现烧伤面积超过25%TBSA的患者T细胞功能明显降低。T细胞功能的降低在烧伤后(PB)第7天开始,并持续到PB第60天。

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